Q fever bioprosthetic aortic valve endocarditis (PVE) successfully treated with doxycycline monotherapy.
Identifieur interne : 004001 ( Main/Exploration ); précédent : 004000; suivant : 004002Q fever bioprosthetic aortic valve endocarditis (PVE) successfully treated with doxycycline monotherapy.
Auteurs : Vitaliy Krol [États-Unis] ; Victoria Kogan ; Burke A. CunhaSource :
- Heart & lung : the journal of critical care [ 1527-3288 ]
Descripteurs français
- KwdFr :
- Adulte, Antibactériens (usage thérapeutique), Chloroquine (usage thérapeutique), Coxiella burnetii, Doxycycline (usage thérapeutique), Endocardite (microbiologie), Endocardite (traitement médicamenteux), Femelle, Fièvre Q (), Fièvre Q (microbiologie), Fièvre Q (traitement médicamenteux), Humains, Prothèse valvulaire cardiaque (effets indésirables), Valve aortique (anatomopathologie), Valve aortique (microbiologie), Valvulopathies (microbiologie), Valvulopathies (traitement médicamenteux).
- MESH :
- anatomopathologie : Valve aortique.
- effets indésirables : Prothèse valvulaire cardiaque.
- microbiologie : Endocardite, Fièvre Q, Valve aortique, Valvulopathies.
- traitement médicamenteux : Endocardite, Fièvre Q, Valvulopathies.
- usage thérapeutique : Antibactériens, Chloroquine, Doxycycline.
- Adulte, Coxiella burnetii, Femelle, Fièvre Q, Humains.
English descriptors
- KwdEn :
- Adult, Anti-Bacterial Agents (therapeutic use), Aortic Valve (microbiology), Aortic Valve (pathology), Chloroquine (therapeutic use), Coxiella burnetii, Doxycycline (therapeutic use), Endocarditis (drug therapy), Endocarditis (microbiology), Female, Heart Valve Diseases (drug therapy), Heart Valve Diseases (microbiology), Heart Valve Prosthesis (adverse effects), Humans, Q Fever (complications), Q Fever (drug therapy), Q Fever (microbiology).
- MESH :
- chemical , therapeutic use : Anti-Bacterial Agents, Chloroquine, Doxycycline.
- adverse effects : Heart Valve Prosthesis.
- complications : Q Fever.
- drug therapy : Endocarditis, Heart Valve Diseases, Q Fever.
- microbiology : Aortic Valve, Endocarditis, Heart Valve Diseases, Q Fever.
- pathology : Aortic Valve.
- Adult, Coxiella burnetii, Female, Humans.
Abstract
Q fever is a zoonotic infection caused by Coxiella burnetii. The most common clinical manifestation of acute Q fever infection is as an atypical community-acquired pneumonia. The pulmonary findings are accompanied by extrapulmonary findings, most typically an increase in serum transaminases and splenomegaly. Because C. burnetii is difficult to culture, the diagnosis of Q fever is usually made serologically. The diagnosis of acute Q fever atypical community-acquired pneumonia is made by demonstrating a fourfold or greater increase in titer between acute and convalescent specimens or by demonstrating elevated immunoglobulin (IgM) (phase II) titers. Chronic Q fever is manifested as granulomatous hepatitis or more commonly as culture-negative endocarditis (CNE). Chronic Q fever (CNE) is a difficult diagnosis because of difficulty in culturing the organism from the blood and the vegetations with Q fever CNE are small or absent. The diagnosis of chronic Q fever CNE is based on serology. Such patients commonly have highly elevated IgM and IgG titers (phase I/II) titers. Chronic Q fever CNE may involve native or prosthetic heart valves. Q fever prosthetic valve endocarditis is rare compared with native valve Q fever endocarditis. Q fever prosthetic valve endocarditis usually requires valve replacement for cure. We present a case of chronic Q fever bioprosthetic aortic valve endocarditis that was successfully treated with doxycycline monotherapy that did not require aortic valve replacement.
DOI: 10.1016/j.hrtlng.2007.04.002
PubMed: 18371509
Affiliations:
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The most common clinical manifestation of acute Q fever infection is as an atypical community-acquired pneumonia. The pulmonary findings are accompanied by extrapulmonary findings, most typically an increase in serum transaminases and splenomegaly. Because C. burnetii is difficult to culture, the diagnosis of Q fever is usually made serologically. The diagnosis of acute Q fever atypical community-acquired pneumonia is made by demonstrating a fourfold or greater increase in titer between acute and convalescent specimens or by demonstrating elevated immunoglobulin (IgM) (phase II) titers. Chronic Q fever is manifested as granulomatous hepatitis or more commonly as culture-negative endocarditis (CNE). Chronic Q fever (CNE) is a difficult diagnosis because of difficulty in culturing the organism from the blood and the vegetations with Q fever CNE are small or absent. The diagnosis of chronic Q fever CNE is based on serology. Such patients commonly have highly elevated IgM and IgG titers (phase I/II) titers. Chronic Q fever CNE may involve native or prosthetic heart valves. Q fever prosthetic valve endocarditis is rare compared with native valve Q fever endocarditis. Q fever prosthetic valve endocarditis usually requires valve replacement for cure. We present a case of chronic Q fever bioprosthetic aortic valve endocarditis that was successfully treated with doxycycline monotherapy that did not require aortic valve replacement.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Cunha, Burke A" sort="Cunha, Burke A" uniqKey="Cunha B" first="Burke A" last="Cunha">Burke A. Cunha</name><name sortKey="Kogan, Victoria" sort="Kogan, Victoria" uniqKey="Kogan V" first="Victoria" last="Kogan">Victoria Kogan</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Krol, Vitaliy" sort="Krol, Vitaliy" uniqKey="Krol V" first="Vitaliy" last="Krol">Vitaliy Krol</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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